Dataset Information
DIA-MS based proteome analysis of HL-60 cells treated with new anti-cancer drug (TAS4464)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Tomoaki Tanaka
PROVIDER: PXD021012 | JPOST Repository | Fri Aug 20 00:00:00 BST 2021
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| PK19012-01_HL60_0h_1.raw | Raw | |||
| PK19012-02_HL60_1h_1.raw | Raw | |||
| PK19012-03_HL60_4h_1.raw | Raw | |||
| PK19012-04_HL60_8h_1.raw | Raw | |||
| PK19012-05_HL60_16h_1.raw | Raw |
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Publications
TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
Oncogene 20210108 7
TAS4464, a potent, selective small molecule NEDD8-activating enzyme (NAE) inhibitor, leads to inactivation of cullin-RING E3 ubiquitin ligases (CRLs) and consequent accumulations of its substrate proteins. Here, we investigated the antitumor properties and action mechanism of TAS4464 in acute myeloid leukemia (AML). TAS4464 induced apoptotic cell death in various AML cell lines. TAS4464 treatments resulted in the activation of both the caspase-9-mediated intrinsic apoptotic pathway and caspase-8 ...[more]
