Proteomics

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Proteomics data of mouse skeletal muscles (microgravity exposure)

ABSTRACT: This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as osteoporosis occurring on the ground by searching serum, bone and skeletal muscle (soleus, extensor digitorum longus) proteomes. The goal of this study is to get better understanding to protect the health of both astronauts and osteoporosis patients. Proteome analyses of skeletal muscles from 12 male C57BL/6J mouse (microgravity with fructo-oligosaccharide (FOS) ingestion, microgravity without FOS ingestion, artificial 1 g with FOS ingestion,and artificial 1 g without FOS ingestion, [n=3, respectively]) were carried out tryptic digestion followed by LC-MS/MS analysis (DDA). The obtained results were searched against UniProt DB by Mascot, and the identified peptides were filtered at 1% FDR threshold by searching against the randomized decoy DB.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Hisashi Hirano 

PROVIDER: PXD021550 | JPOST Repository | Fri Jul 30 00:00:00 BST 2021

REPOSITORIES: jPOST

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Action DRS
171011Elite_Sol_10.raw Raw
171011Elite_Sol_11.raw Raw
171011Elite_Sol_12.raw Raw
171011Elite_Sol_5.raw Raw
171011Elite_Sol_6.raw Raw
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Publications

Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice.

Ohira Takashi T   Ino Yoko Y   Kimura Yayoi Y   Nakai Yusuke Y   Kimura Ayuko A   Kurata Yoichi Y   Kagawa Hiroyuki H   Kimura Mitsuo M   Egashira Kenji K   Matsuda Chie C   Ohira Yoshinobu Y   Furukawa Satoshi S   Hirano Hisashi H  

NPJ microgravity 20210917 1

Short-chain fatty acids produced by the gut bacterial fermentation of non-digestible carbohydrates, e.g., fructo-oligosaccharide (FOS), contribute to the maintenance of skeletal muscle mass and oxidative metabolic capacity. We evaluated the effect of FOS ingestion on protein expression of soleus (Sol) and extensor digitorum longus muscles in mice exposed to microgravity (μ-g). Twelve 9-week-old male C57BL/6J mice were raised individually on the International Space Station under μ-g or artificial  ...[more]

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