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KIF1A Motor-Neck domain interaction

ABSTRACT: Quantitative Analysis of Motor-Neck Interaction by the Combination of Protein Painting and Stable Isotope Tags Labelling

ORGANISM(S): Sus Scrofa

SUBMITTER: Tadayuki Ogawa

PROVIDER: PXD026083 | JPOST Repository | Thu Dec 23 00:00:00 GMT 2021

REPOSITORIES: jPOST

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A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle.

Morikawa Manatsu M Jerath Nivedita U NU Ogawa Tadayuki T Morikawa Momo M Tanaka Yosuke Y Shy Michael E ME Zuchner Stephan S Hirokawa Nobutaka N

The EMBO journal 20220208 5

The mechanochemical coupling of ATPase hydrolysis and conformational dynamics in kinesin motors facilitates intramolecular interaction cycles between the kinesin motor and neck domains, which are essential for microtubule-based motility. Here, we characterized a charge-inverting KIF1A-E239K mutant that we identified in a family with axonal-type Charcot-Marie-Tooth disease and also in 24 cases in human neuropathies including spastic paraplegia and hereditary sensory and autonomic neuropathy. We s ...[more]

PMID: 35132656

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