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Fetal growth restriction_pancreas_differences in nutritional condition

ABSTRACT: Quantification of proteins in the pancreas of fetal growth restriction.

ORGANISM(S): Rattus Rattus (black Rat)

SUBMITTER: Atsuto Onoda

PROVIDER: PXD026502 | JPOST Repository | Tue Jun 07 00:00:00 BST 2022

REPOSITORIES: jPOST

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Publications

Fetal growth restriction followed by early catch-up growth impairs pancreatic islet morphology in male rats.

Jabary Mahboba M Onoda Atsuto A Kitase Yuma Y Ueda Kazuto K Mimatsu Haruka H Go Shoji S Miura Ryosuke R Tsuji Masahiro M Takahashi Yoshiyuki Y Hayakawa Masahiro M Sato Yoshiaki Y

Scientific reports 20230215 1

Fetal growth restriction (FGR), followed by postnatal early catch-up growth, is associated with an increased risk of metabolic dysfunction, including type 2 diabetes in humans. This study aims to determine the effects of FGR and early catch-up growth after birth on the pathogenesis of type 2 diabetes, with particular attention to glucose tolerance, pancreatic islet morphology, and fibrosis, and to elucidate its mechanism using proteomics analysis. The FGR rat model was made by inducing mild intr ...[more]

PMID: 36792668

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