Dataset Information
MS-CETSA discovery of target engagement by Darapladib
Ontology highlight
ABSTRACT:
ORGANISM(S): Plasmodium Falciparum
SUBMITTER: Jerzy Michal Dziekan, Zbynek Bozdech
PROVIDER: PXD029803 | JPOST Repository | Wed May 18 00:00:00 BST 2022
REPOSITORIES: jPOST
Dataset's files
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Publications
Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target.
Cell reports 20220601 11
The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate that Plasmodium falciparum imports a host antioxidant enzyme, peroxiredoxin 6 (PRDX6), during hemoglobin uptake from the red blood cell cytosol. PRDX6 is a lipid-peroxidation repair enzyme with phospholipase A<sub>2</sub> (PLA<sub>2</sub>) activity. Inhibition ...[more]