Proteomics

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MS analysis of phosphopeptides enriched from the lumbar spinal cord of SOD1G93A mice at 20weeks.


ABSTRACT: This project is "Phosphoproteomic analysis of the lumbar spinal cord, a lesion site in the amyotrophic lateral sclerosis (ALS) mouse model SOD1G93A mice". The aim of this study is to clarify the phosphorylation changes by the lumbar spinal cord of SOD1G93A mice at 20w by applying proteomics technology. The goal of this study is to better understand the pathogenesis of ALS. lumbar spinal cord of SOD1G93A mice (n=5) and WT mice (n=4) were collected at 20w, and the phosphoproteomics were compared.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Fumiaki Tanaka 

PROVIDER: PXD030651 | JPOST Repository | Thu May 19 00:00:00 BST 2022

REPOSITORIES: jPOST

Dataset's files

Source:
Action DRS
190401QE_P10.mznld Other
190401QE_P10.raw Raw
190401QE_P2.mznld Other
190401QE_P2.raw Raw
190401QE_P3.mznld Other
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Publications


Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder that affects upper and lower motor neurons; however, its pathomechanism has not been fully elucidated. Using a comprehensive phosphoproteomic approach, we have identified elevated phosphorylation of Collapsin response mediator protein 1 (Crmp1) at serine 522 in the lumbar spinal cord of ALS model mice overexpressing a human superoxide dismutase mutant (SOD1<sup>G93A</sup>). We investigated the effec  ...[more]

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