Dataset Information
Brain microvascular endothelial cells: PODXL KD
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Sumimo Ohtsuki
PROVIDER: PXD030652 | JPOST Repository | Fri Mar 11 00:00:00 GMT 2022
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 210613_shNT_CM2.wiff.scan | Wiff | |||
| 210613_shNT_CM3.wiff | Wiff | |||
| 210613_shNT_CM3.wiff.dia | Wiff | |||
| 210613_shNT_CM3.wiff.dia.quant | Wiff | |||
| 210613_shNT_CM_mix_IDA.wiff | Wiff |
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Publications
Knockdown of Podocalyxin Post-Transcriptionally Induces the Expression and Activity of ABCB1/MDR1 in Human Brain Microvascular Endothelial Cells.
Journal of pharmaceutical sciences 20220217 6
Podocalyxin (PODXL) is a highly sialylated transmembrane protein that is expressed on the luminal membrane of brain microvascular endothelial cells. To clarify the role of PODXL in the blood-brain barrier (BBB), the present study aimed to investigate the effect of PODXL-knockdown on protein expression, especially the expression of ABCB1/MDR1, in human microvascular endothelial cells (hCMEC/D3). By quantitative proteomics, gene ontology enrichment with differentially expressed proteins showed tha ...[more]
