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KH_dKO: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe hypoplasia of skeletal muscles in young mice

ABSTRACT: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe hypoplasia of skeletal muscles in young mice

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Keisuke Hitachi

PROVIDER: PXD032244 | JPOST Repository | Mon Nov 28 00:00:00 GMT 2022

REPOSITORIES: jPOST

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			Action	DRS
	20211015_06_WT_07_Uni130m2uL.raw	Raw
	20211015_08_WT_08_Uni130m2uL.raw	Raw
	20211015_10_WT_11_Uni130m2uL.raw	Raw
	20211015_12_dKO_09_Uni130m2uL.raw	Raw
	20211015_14_dKO_10_Uni130m2uL.raw	Raw

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Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.

Hitachi Keisuke K Kiyofuji Yuri Y Yamaguchi Hisateru H Nakatani Masashi M Inui Masafumi M Tsuchida Kunihiro K

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20230101 1

The skeletal muscle myosin heavy chain (MyHC) is a fundamental component of the sarcomere structure and muscle contraction. Two of the three adult fast MyHCs, MyHC-IIx and MyHC-IIb, are encoded by Myh1 and Myh4, respectively. However, skeletal muscle disorders have not yet been linked to these genes in humans. MyHC-IIb is barely detectable in human skeletal muscles. Thus, to characterize the molecular function of skeletal muscle MyHCs in humans, investigation of the effect of simultaneous loss o ...[more]

PMID: 36515178

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