Dataset Information
Identification of CLPX binding proteins in FT293 cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Ko Suzuki
PROVIDER: PXD032346 | JPOST Repository | Thu Mar 17 00:00:00 GMT 2022
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| CLPX-FLAG_1.raw | Raw | |||
| CLPX-FLAG_2.raw | Raw | |||
| CLPX-FLAG_3.raw | Raw | |||
| CLPX_OTC-LucF.xlsx | Xlsx | |||
| OTC-LucF_1.raw | Raw |
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Publications
CLPX regulates mitochondrial fatty acid β-oxidation in liver cells.
The Journal of biological chemistry 20230903 10
Mitochondrial fatty acid oxidation (β-oxidation) is an essential metabolic process for energy production in eukaryotic cells, but the regulatory mechanisms of this pathway are largely unknown. In the present study, we found that several enzymes involved in β-oxidation are associated with CLPX, the AAA+ unfoldase that is a component of the mitochondrial matrix protease ClpXP. The suppression of CLPX expression increased β-oxidation activity in the HepG2 cell line and in primary human hepatocytes ...[more]
