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Project Title: Proteome analysis of CD4+ T cell subsets

ABSTRACT: Functionally distinct CD4+ helper T (Th) cell subsets, such as Th1, Th2, Th17, and regulatory T cells (Treg), play a pivotal role in the host-defense against pathogen invasion and the pathogenesis of inflammatory disorders. In this project, DIA-MS-based proteome analysis was performed on naïve CD4+ T, Th0, Th1, Th2, Th17 and iTreg cells using Q Exactive HF-X (Thermo Fisher Scientific) to search for proteins that differ among the cell subsets.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yusuke Endo

PROVIDER: PXD036065 | JPOST Repository | Wed Jan 04 00:00:00 GMT 2023

REPOSITORIES: jPOST

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			Action	DRS
	Naive_CD4_T-Cell_1.raw	Raw
	Naive_CD4_T-Cell_2.raw	Raw
	Naive_CD4_T-Cell_3.raw	Raw
	Naive_CD4_T-Cell_4.raw	Raw
	Th0_1.raw	Raw

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Publications

Characterization of proteogenomic signatures of differentiation of CD4+ T cell subsets.

Kanno Toshio T Konno Ryo R Miyako Keisuke K Nakajima Takahiro T Yokoyama Satoru S Sasamoto Shigemi S Asou Hikari K HK Ohzeki Junichiro J Kawashima Yusuke Y Hasegawa Yoshinori Y Ohara Osamu O Endo Yusuke Y

DNA research : an international journal for rapid publication of reports on genes and genomes 20230201 1

Functionally distinct CD4+ helper T (Th) cell subsets, including Th1, Th2, Th17, and regulatory T cells (Treg), play a pivotal role in the regulation of acquired immunity. Although the key proteins involved in the regulation of Th cell differentiation have already been identified how the proteogenomic landscape changes during the Th cell activation remains unclear. To address this issue, we characterized proteogenomic signatures of differentiation to each Th cell subsets by RNA sequencing and li ...[more]

PMID: 36579714

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