Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Hidetaka Kosako
PROVIDER: PXD039092 | JPOST Repository | Sat Dec 24 00:00:00 GMT 2022
REPOSITORIES: jPOST
Items per page: 5 1 - 5 of 6 |
Horii Yuma Y Matsuda Shoichi S Toyota Chikashi C Morinaga Takumi T Nakaya Takeo T Tsuchiya Soken S Ohmuraya Masaki M Hironaka Takanori T Yoshiki Ryo R Kasai Kotaro K Yamauchi Yuto Y Takizawa Noburo N Nagasaka Akiomi A Tanaka Akira A Kosako Hidetaka H Nakaya Michio M
Nature communications 20230208 1
Myofibroblasts cause tissue fibrosis by producing extracellular matrix proteins, such as collagens. Humoral factors like TGF-β, and matrix stiffness are important for collagen production by myofibroblasts. However, the molecular mechanisms regulating their ability to produce collagen remain poorly characterised. Here, we show that vestigial-like family member 3 (VGLL3) is specifically expressed in myofibroblasts from mouse and human fibrotic hearts and promotes collagen production. Further, subs ...[more]