Proteomics

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Identification of gravity-responsive proteins in mouse soleus muscle using proteomic analysis

ABSTRACT: This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as osteoporosis occurring on the ground by searching serum, bone and skeletal muscle (soleus, extensor digitorum longus) proteomes. The goal of this study is to get better understanding to protect the health of both astronauts and osteoporosis patients. Proteome analyses of skeletal muscles from male C57BL/6J mouse (spaceflight [n=6], hypergravity [n=5], hindlimb unloading [n=5]) were carried out tryptic digestion followed by LC-MS/MS analysis (DDA). The obtained results were searched against UniProt DB by Mascot, and the identified peptides were filtered at 1% FDR threshold by searching against the decoy DB.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yayoi Kimura 

PROVIDER: PXD041190 | JPOST Repository | Tue Sep 19 00:00:00 BST 2023

REPOSITORIES: jPOST

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Action DRS
170626Elite_Sol_10.raw Raw
170626Elite_Sol_11.raw Raw
170626Elite_Sol_12.raw Raw
170626Elite_Sol_2.raw Raw
170626Elite_Sol_3.raw Raw
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Publications

Identification of mouse soleus muscle proteins altered in response to changes in gravity loading.

Ino Yoko Y   Ohira Takashi T   Kumagai Ken K   Nakai Yusuke Y   Akiyama Tomoko T   Moriyama Kayano K   Takeda Yuriko Y   Saito Tomoyuki T   Ryo Akihide A   Inaba Yutaka Y   Hirano Hisashi H   Kimura Yayoi Y  

Scientific reports 20230922 1

Gravity-dependent physical processes strongly affect the ability of elderly people to maintain musculoskeletal health by reducing muscle atrophy and increasing bone mineral density, thereby increasing quality of life. A need therefore exists to identify molecules in the musculoskeletal system that are responsive to gravitational loading and to establish an objective indicator for the maintenance of healthy musculoskeletal systems. Here, we performed an integrated assessment of the results of sol  ...[more]

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