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Comprehensive human serum spectral library

ABSTRACT: For a comprehensive analysis of the human serum proteome, we constructed a spectral library for DIA-MS. Our spectral library contained information on 20,303 peptides derived from 1,597 human serum proteins. We believe that the constructed spectral library will be useful for proteomic analysis of human serum by DIA-MS.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yayoi Kimura

PROVIDER: PXD041558 | JPOST Repository | Wed Apr 10 00:00:00 BST 2024

REPOSITORIES: jPOST

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			Action	DRS
	170609QE_PAN_Serum_Fra24.raw	Raw
	170609QE_PAN_Serum_Fra25.raw	Raw
	170609QE_PAN_Serum_Fra26.raw	Raw
	170609QE_PAN_Serum_Fra27.raw	Raw
	170609QE_PAN_Serum_Fra28.raw	Raw

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Publications

Use of data-independent acquisition mass spectrometry to identify an objective serum indicator of the need for osteoporotic therapeutic intervention.

Nakai Yusuke Y Kumagai Ken K Ino Yoko Y Akiyama Tomoko T Moriyama Kayano K Takeda Yuriko Y Egashira Kenji K Ohira Takashi T Ryo Akihide A Saito Tomoyuki T Inaba Yutaka Y Hirano Hisashi H Kimura Yayoi Y

Journal of proteomics 20240402

Osteoporosis is characterized by weakened bone microstructure and loss of bone mass. Current diagnostic criteria for osteoporosis are based on the T-score, which is a measure of bone mineral density. However, osteoporotic fragility fractures can occur regardless of the T-score, underscoring the need for additional criteria for the early detection of patients at fracture risk. To identify indicators of reduced bone strength, we performed serum proteomic analysis using data-independent acquisition ...[more]

PMID: 38574990

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