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Nuclear proteome of cortical neurons of young and aged mice

ABSTRACT: Mass spectrometry analysis of NeuN-positive neuronal nuclei from cortices of young and aged mice

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yusuke Kishi

PROVIDER: PXD041560 | JPOST Repository | Fri Jul 21 00:00:00 BST 2023

REPOSITORIES: jPOST

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			Action	DRS
	KY12_1_1_YT.raw	Raw
	KY12_2_1_AT.raw	Raw
	KY12_3_1_YT.raw	Raw
	KY12_4_1_AT.raw	Raw
	KY12_5_1_YT.raw	Raw

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1 - 5 of 7

Publications

Age-associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex.

Frey Tanita T Murakami Tomonari T Maki Koichiro K Kawaue Takumi T Tani Naoki N Sugai Ayaka A Nakazawa Naotaka N Ishiguro Kei-Ichiro KI Adachi Taiji T Kengaku Mineko M Ohki Kenichi K Gotoh Yukiko Y Kishi Yusuke Y

Aging cell 20230721 9

Neurons decline in their functionality over time, and age-related neuronal alterations are associated with phenotypes of neurodegenerative diseases. In nonneural tissues, an infolded nuclear shape has been proposed as a hallmark of aged cells and neurons with infolded nuclei have also been reported to be associated with neuronal activity. Here, we performed time-lapse imaging in the visual cortex of Nex-Cre;SUN1-GFP mice. Nuclear infolding was observed within 10 min of stimulation in young nucle ...[more]

PMID: 37476844

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