Proteomics

Dataset Information

0

Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice

ABSTRACT: This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in spaceflight-induced deterioration of musculo-skeletal system as well as skeletal muscle atrophy and osteoporosis occurring on the ground by searching serum, bone and skeletal muscle proteomes. The goal of this study is to get better understanding to protect the health of both astronauts and osteoporosis patients. Proteome analyses of gestrocnemius muscles from male C57BL/6J mouse (microgravity and artificial 1-g [n=6, respectively]) were carried out tryptic digestion followed by LC-MS/MS analysis (DDA). The obtained results were searched against UniProt DB by Mascot, and the identified peptides were filtered at 1% FDR threshold by searching against the decoy DB.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yayoi Kimura 

PROVIDER: PXD041806 | JPOST Repository | Thu Feb 01 00:00:00 GMT 2024

REPOSITORIES: jPOST

Json Xml

Dataset's files

Source:
Action DRS
220425Elite_Gast_A1G_Outside_ins_4.raw Raw
220425Elite_Gast_A1G_Outside_ins_5.raw Raw
220425Elite_Gast_A1G_Outside_ins_6.raw Raw
220425Elite_Gast_A1G_Outside_sol_1.raw Raw
220425Elite_Gast_A1G_Outside_sol_2.raw Raw
Items per page:
1 - 5 of 20
altmetric image

Publications

Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.

Ohira Takashi T   Ino Yoko Y   Kawao Naoyuki N   Mizukami Yuya Y   Okada Kiyotaka K   Matsuo Osamu O   Hirano Hisashi H   Kimura Yayoi Y   Kaji Hiroshi H  

Journal of applied physiology (Bethesda, Md. : 1985) 20240208 3

Mechanical-unloading-induced skeletal muscle atrophy results in physical frailty and disability. Elucidating its mechanism is required to establish effective countermeasures for this muscle adaptation. First, we analyzed the proteome profile in the gastrocnemius (Gast) and soleus muscles of space-flown mice raised under microgravity or artificial 1-<i>g</i> for 30 days, and found that the expression levels of fibrinolysis-related proteins were significantly elevated in the mechanical-unloaded mu  ...[more]

Similar Datasets

Proteomics Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice [Reanalysis: JPST002136]
2024-09-13 | RPXD055690 | JPOST Repository
Proteomics Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice [Reanalysis: JPST002136]
2024-09-13 | RPXD055697 | JPOST Repository
Proteomics Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice [Reanalysis: JPST002136]
2024-09-13 | RPXD055693 | JPOST Repository
Proteomics Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice [Reanalysis: JPST002136]
2024-09-13 | RPXD055692 | JPOST Repository
Proteomics Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice [Reanalysis: JPST002136]
2024-09-13 | RPXD055691 | JPOST Repository
Proteomics Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice [Reanalysis: JPST002136]
2024-09-13 | RPXD055696 | JPOST Repository
Proteomics Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice [Reanalysis: JPST002136]
2024-09-13 | RPXD055695 | JPOST Repository
Proteomics Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice [Reanalysis: JPST002136]
2024-09-13 | RPXD055694 | JPOST Repository
Proteomics Proteomics data of mouse skeletal muscles (hypergravity exposure) [Reanalysis: JPST000736]
2024-09-13 | RPXD055652 | JPOST Repository
Proteomics Proteomics data of mouse skeletal muscles (hypergravity exposure) [Reanalysis: JPST000736]
2024-09-13 | RPXD055655 | JPOST Repository