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An aspartyl pseudoprotease dominates the secretory hydrolase landscape of the skin commensal Malassezia in situ

ABSTRACT: Malassezia globosa is abundant and prevalent on sebaceous areas of the human skin. Genome annotation reveals that M. globosa possesses a repertoire of secreted hydrolytic enzymes relevant for lipid and protein metabolism on the skin. In-gel proteomics identifies a predicted aspartyl protease, MGL_3331, which is highly expressed on both healthy and disease-affected dermatological sites.

ORGANISM(S): Cellular Organisms

SUBMITTER: Li Hao

PROVIDER: PXD042508 | JPOST Repository | Thu Nov 23 00:00:00 GMT 2023

REPOSITORIES: jPOST

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			Action	DRS
	20221205_Uniprot_Malasseziaglobosa_reference_withisoforms.fasta	Fasta
	20221205_ZS_SW_Wisely_CBS_7966_supt.msf	Msf
	20221205_ZS_SW_Wisely_CBS_7966_supt.pdResult	Other
	20221205_ZS_SW_Wisely_CBS_7966_supt.pdResultView	Other
	20221205_ZS_SW_Wisely_CBS_7966_supt.raw	Raw

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Publications

A Malassezia pseudoprotease dominates the secreted hydrolase landscape and is a potential allergen on skin.

Chua Wisely W Marsh Carl O CO Poh Si En SE Koh Winston Lc WL Lee Melody Li Ying MLY Koh Li Fang LF Tang Xin-Zi Emily XE See Peter P Ser Zheng Z Wang Shi Mei SM Sobota Radoslaw M RM Dawson Thomas L TL Yew Yik Weng YW Thng Steven S O'Donoghue Anthony J AJ Oon Hazel H HH Common John E JE Li Hao H

Biochimie 20230924

Malassezia globosa is abundant and prevalent on sebaceous areas of the human skin. Genome annotation reveals that M. globosa possesses a repertoire of secreted hydrolytic enzymes relevant for lipid and protein metabolism. However, the functional significance of these enzymes is uncertain and presence of these genes in the genome does not always translate to expression at the cutaneous surface. In this study we utilized targeted RNA sequencing from samples isolated directly from the skin to quant ...[more]

PMID: 37748748

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Distribution of RESV and its metabolite peaks in mouse tissues after oral and skin administration

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Absorption efficiency of RESV through mouse skin using 3 bases in different tissues

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Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin

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The proteome of hand eczema assessed by tape stripping

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