Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk

ABSTRACT: Proteomics from mouse inguinal white adipose tissue at 7 days post-burn and 30-days post-burn.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Marc Jeschke

PROVIDER: PXD047283 | JPOST Repository | Tue Nov 28 00:00:00 GMT 2023

REPOSITORIES: jPOST

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	20210623_Ex480_CDS_AijazA_Mouse_LFQ_Results.mgf	Mgf
	20210623_Ex480_CDS_AijazA_Mouse_LFQ_Results.msf	Msf
	20210623_Ex480_CDS_AijazA_Mouse_LFQ_Results.mzid	Mzid
	20210709_Ex480_CDS_AijazA_B1-2.raw	Raw
	20210709_Ex480_CDS_AijazA_B3-4.raw	Raw

Items per page:

1 - 5 of 10

Similar Datasets

Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk.

Project description:Severe burns induce a chronic hypermetabolic state that persists well past wound closure, indicating that additional internal mechanisms must be involved. Adipose tissue is suggested to be a central regulator in perpetuating hypermetabolism, although this has not been directly tested. Here, we show that thermogenic adipose tissues are activated in parallel to increases in hypermetabolism independent of cold stress. Using an adipose tissue transplantation model, we discover that burn-derived subcutaneous white adipose tissue alone is sufficient to invoke a hypermetabolic response in a healthy recipient mouse. Concomitantly, transplantation of healthy adipose tissue alleviates metabolic dysfunction in a burn recipient. We further show that the nicotinic acetylcholine receptor signaling pathway may mediate an immune-adipose crosstalk to regulate adipose tissue remodeling post-injury. Targeting this pathway could lead to innovative therapeutic interventions to counteract hypermetabolic pathologies.

| S-EPMC10845122 | biostudies-literature

Brown fat-specific YY1 deficiency effect on subcutaneous white adipose tissue

Project description:Analysis of visceral white adipose tissue (EWAT) from Yin Yang 1 adipose-specific knockout mice exposed to cold (4ºC) for 4 days.

2015-11-10 | GSE70562 | GEO

Ubiquitin independent degradation pathway regulates browning of white adipose tissue

Project description:Obesity is a significant risk factor for diabetes, cardiovascular diseases, and certain cancers, and manifests as excessive fat accumulation. The browning of white adipose tissue (WAT) represents one of the most promising strategies for preventing and treating obesity and metabolic diseases. To date, an increasing number of studies have focused on key molecular mechanisms regulating fat thermogenesis, laying the foundation for effective intervention strategies.We analyzed the differentially expressed proteins in white adipose tissue of the inguinal region using mass spectrometry.

2024-08-29 | PXD055441 |

Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver

Project description:Cold exposure imposes a metabolic challenge to mammals that must be met by a coordinated repsonse in different tissues to prevent hypothermia. This study reports analysis of transcriptome profiles in brown adipose tissue, liver, white adipose of mice in repsonse to 24 hour cold exposure Total RNA was extracted from brown adipose, whie adipose and liver from cold treated and control plants. 3 replicates of brown adipose and white adipose and 2 replicates of liver samples.

2013-07-08 | E-GEOD-44138 | biostudies-arrayexpress

Brown fat-specific YY1 deficiency effect on subcutaneous white adipose tissue

Project description:Analysis of visceral white adipose tissue (EWAT) from Yin Yang 1 adipose-specific knockout mice exposed to cold (4ºC) for 4 days. Control mice YY1flox/flox versus YY1flox/flox; Adiponectin Cre were cold exposed for 4 days.

2015-11-10 | E-GEOD-70562 | biostudies-arrayexpress

Genome-wide maps of 5hmC levels in mouse Inguinal white adipose tissue

Project description:Using high throughput sequencing we report 5hmC levels, and gene expression changes in mouse Inguinal white adipose tissue upon exposure to room temperature and 7 days to cold in Tet1 floxed wild-type control and adipose selectiveTet1 KO mice.

2020-06-24 | GSE153092 | GEO

Cold induced mouse interscapular brown and inguinal white adipose tissue

Project description:Adult mouse were cold induced, RNAseq was performed for interscapular brown and inguinal white adipose tissue

2019-08-05 | E-MTAB-7565 | biostudies-arrayexpress

Dose-dependent changes in gonadal white adipose tissue in TCDD-elicited steatohepatitis

Project description:Bulk RNA-sequencing of 27 C57BL/6 gonadal white adipose tissue samples where ovariectomized females were gavaged 4 days for 92 days with 0.01 to 30 µg/kg TCDD or sesame oil vehicle (n = 3) per dose.

2024-10-29 | GSE272683 | GEO

Rat white adipose tissue DIGE-LC-MSMS

Project description:White adipose tissue is a central place to energy storage and a major endocrine organ. However, adipose molecular mechanisms have been poorly studied during prolonged fasting. To fill this gap, the aim of this study was to decipher proteomic regulations in rat adipose tissue during phase 2 (lipid mobilization) and phase 3 (protein catabolism) of prolonged fasting compared to the fed state. Specific responses reflecting adipose tissue inflammation, increased fibrinolysis and a possible protein catabolism-related energy saving mechanism were recorded during phase 3. Differences between internal and subcutaneous adipose tissues were essentially related to lipid metabolism, the response to oxidative stress and energy production. These data thus provide a molecular basis of adipose tissue responses according to the fasting stage.

2021-02-24 | PXD010902 | Pride

Brown versus white tissue adipose selective genes

Project description:The aim of this study was to identify genes expressed selectively in brown adipose tissue as compared to white adipose tissue from the same animals. This analysis provides a gene set that is brown and white adipose selective. Keywords: tissue comparison from mice

2007-06-08 | GSE8044 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data