Quantitative Proteomic Analysis of Residual Host Cell Protein Retention Across Adeno- Associated Virus (AAV) Affinity Chromatography
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ABSTRACT: To better understand host cell protein (HCP) retention in adeno-associated virus (AAV) downstream processes, sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) was used to quantitatively profile residual HCPs for four AAV serotypes (2, 5, 8, and 9) produced with HEK293 cells and purified using POROS™ CaptureSelect™ AAVX affinity chromatography.
ORGANISM(S): Cellular Organisms
SUBMITTER: Kelvin H. Lee
PROVIDER: PXD056294 | JPOST Repository | Thu Dec 12 00:00:00 GMT 2024
REPOSITORIES: jPOST
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