Ontology highlight
ABSTRACT:
PROVIDER: MSV000078456 | MassIVE | Thu Jul 04 00:00:00 BST 2013
REPOSITORIES: MassIVE
Lambert Jean-Philippe JP Ivosev Gordana G Couzens Amber L AL Larsen Brett B Taipale Mikko M Lin Zhen-Yuan ZY Zhong Quan Q Lindquist Susan S Vidal Marc M Aebersold Ruedi R Pawson Tony T Bonner Ron R Tate Stephen S Gingras Anne-Claude AC
Nature methods 20131027 12
Characterizing changes in protein-protein interactions associated with sequence variants (e.g., disease-associated mutations or splice forms) or following exposure to drugs, growth factors or hormones is critical to understanding how protein complexes are built, localized and regulated. Affinity purification (AP) coupled with mass spectrometry permits the analysis of protein interactions under near-physiological conditions, yet monitoring interaction changes requires the development of a robust ...[more]