Ontology highlight
ABSTRACT:
PROVIDER: MSV000078494 | MassIVE | Wed Nov 20 11:06:00 GMT 2013
REPOSITORIES: MassIVE
Molecular & cellular proteomics : MCP 20111209 4
The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing both biophysical and biochemical cues that are important regulators of cell proliferation, survival, differentiation, and migration. We present here a proteomic strategy developed to characterize the in vivo ECM composition of normal tissues and tumors using enrichment of protein extracts for ECM components and subsequent analysis by mass spectrometry. In parallel, we have developed a bioinformatic approach t ...[more]