Proteomics

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The matrisome: in silico definition and in vivo characterization of tumor extracellular matrix

ABSTRACT: Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO. Mol Cell Proteomics 2012, 11: M111.014647. doi:10.1074/mcp.M111.014647. PMCID:PMC3322572. Tranche_hash:onoKvMCC9umP0dW2GlZSGN/DVfz6tqoyRvsA16h351RjGJZiqjk0wWGYQB9+zPpRj+ASAgKsd779N0Td4250FCPJ6jUAAAAAAABFoQ==

PROVIDER: MSV000078494 | MassIVE | Wed Nov 20 11:06:00 GMT 2013

REPOSITORIES: MassIVE

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The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

Naba Alexandra A   Clauser Karl R KR   Hoersch Sebastian S   Liu Hui H   Carr Steven A SA   Hynes Richard O RO  

Molecular & cellular proteomics : MCP 20111209 4

The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing both biophysical and biochemical cues that are important regulators of cell proliferation, survival, differentiation, and migration. We present here a proteomic strategy developed to characterize the in vivo ECM composition of normal tissues and tumors using enrichment of protein extracts for ECM components and subsequent analysis by mass spectrometry. In parallel, we have developed a bioinformatic approach t  ...[more]

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