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Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.

ABSTRACT: Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10.1016/j.cell.2011.10.022. Tranche hash:HTWY5ZeSLM1hyYEyfEiJREkgLXs6BZxCczuixy9XjULsync5HCkXx/8gB7nZKpGocwOnt8vOk/Q3cpbPh/ycD/2LT0AAAAAAAAAuEg==

OTHER RELATED OMICS DATASETS IN: PRJNA138967

PROVIDER: MSV000078507 | MassIVE | Tue Dec 10 11:58:00 GMT 2013

REPOSITORIES: MassIVE

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Systematic discovery of TLR signaling components delineates viral-sensing circuits.

Chevrier Nicolas N Mertins Philipp P Artyomov Maxim N MN Shalek Alex K AK Iannacone Matteo M Ciaccio Mark F MF Gat-Viks Irit I Tonti Elena E DeGrace Marciela M MM Clauser Karl R KR Garber Manuel M Eisenhaure Thomas M TM Yosef Nir N Robinson Jacob J Sutton Amy A Andersen Mette S MS Root David E DE von Andrian Ulrich U Jones Richard B RB Park Hongkun H Carr Steven A SA Regev Aviv A Amit Ido I Hacohen Nir N

Cell 20111101 4

Deciphering the signaling networks that underlie normal and disease processes remains a major challenge. Here, we report the discovery of signaling components involved in the Toll-like receptor (TLR) response of immune dendritic cells (DCs), including a previously unkown pathway shared across mammalian antiviral responses. By combining transcriptional profiling, genetic and small-molecule perturbations, and phosphoproteomics, we uncover 35 signaling regulators, including 16 known regulators, inv ...[more]

PMID: 22078882

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