Proteomics

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Extracellular Matrix Signatures of Human Mammary Carcinoma Identify Novel Metastasis Promoters

ABSTRACT: Naba A, Clauser K.R, Lamar J.M, Carr S.A and Hynes RO. eLife 2014

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Steven A. Carr 

PROVIDER: MSV000078535 | MassIVE | Mon Jan 27 18:17:00 GMT 2014

REPOSITORIES: MassIVE

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Publications

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.

Naba Alexandra A   Clauser Karl R KR   Lamar John M JM   Carr Steven A SA   Hynes Richard O RO  

eLife 20140311

The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing metastatic potential differ in ECM composition. Both tumor cells and stromal cells contribute to the tumor matrix and tumors of differing metastatic ability differ in both tumor- and stroma-derived ECM components. We define ECM signatures of poorly  ...[more]