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Selective killing of cancer cells by a small molecule targeting the stress response to ROS

ABSTRACT: Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Nature. 2011 475:231-4. doi: 10.1038/nature10167. PMCID: PMC3316487

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Steven A. Carr

PROVIDER: MSV000078537 | MassIVE | Mon Jan 27 19:11:00 GMT 2014

REPOSITORIES: MassIVE

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Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj Lakshmi L Ide Takao T Gurkar Aditi U AU Foley Michael M Schenone Monica M Li Xiaoyu X Tolliday Nicola J NJ Golub Todd R TR Carr Steven A SA Shamji Alykhan F AF Stern Andrew M AM Mandinova Anna A Schreiber Stuart L SL Lee Sam W SW

Nature 20110713 7355

Malignant transformation, driven by gain-of-function mutations in oncogenes and loss-of-function mutations in tumour suppressor genes, results in cell deregulation that is frequently associated with enhanced cellular stress (for example, oxidative, replicative, metabolic and proteotoxic stress, and DNA damage). Adaptation to this stress phenotype is required for cancer cells to survive, and consequently cancer cells may become dependent upon non-oncogenes that do not ordinarily perform such a vi ...[more]

PMID: 21753854

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