Proteomics

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Extracellular Matrix Signatures of Human Primary Metastatic Colon Cancers and their Liver Metastases

ABSTRACT: Naba A, Clauser KR, Whittaker CA,Carr SA, Tanabe KK, Hynes RO. 2014

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Steven A. Carr 

PROVIDER: MSV000078555 | MassIVE | Thu Feb 20 17:25:00 GMT 2014

SECONDARY ACCESSION(S): PXD001092

REPOSITORIES: MassIVE

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Publications

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

Naba Alexandra A   Clauser Karl R KR   Whittaker Charles A CA   Carr Steven A SA   Tanabe Kenneth K KK   Hynes Richard O RO  

BMC cancer 20140718

<h4>Background</h4>Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel prognostic and diagnostic tools as well as novel therapeutic strategies are still needed to monitor and target colon cancer progression. We and others have previously shown, using mouse models, that the extracellular matrix (ECM), a major  ...[more]