Proteomics,Multiomics

Dataset Information

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Raj_nSR100_interactions_P36_V21_P105_V17

ABSTRACT: This submission includes the mass spectrometry data for the manuscript by Raj et al. (nSR100 regulation of an exon network required for neurogenesis). This submission contains files for Srrm4 (aka nSR100) interactions from mouse N2A cells acquired on a 5600 TripleTOF mass spectrometer and files for SRRM4 interactions from human HEK293T cells acquired on an LTQ. See the README file within "Methods and Protocols" and the accompanying File description.

OTHER RELATED OMICS DATASETS IN: PRJNA246157

INSTRUMENT(S): TripleTOF 5600, LTQ

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Anne-Claude Gingras 

PROVIDER: MSV000078609 | MassIVE | Wed Apr 23 13:26:00 BST 2014

SECONDARY ACCESSION(S): PXD001308

REPOSITORIES: MassIVE

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Publications

The vertebrate and neural-specific Ser/Arg (SR)-related protein nSR100/SRRM4 regulates an extensive program of alternative splicing with critical roles in nervous system development. However, the mechanism by which nSR100 controls its target exons is poorly understood. We demonstrate that nSR100-dependent neural exons are associated with a unique configuration of intronic cis-elements that promote rapid switch-like regulation during neurogenesis. A key feature of this configuration is the insert  ...[more]

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