The S. cerevisiae SUMO stress response is a transcription-dependent conjugation-deconjugation cycle
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ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932)
SUBMITTER: Brian Raught
PROVIDER: MSV000078739 | MassIVE | Mon Jun 16 05:33:00 BST 2014
REPOSITORIES: MassIVE
Publications
The S. cerevisiae SUMO stress response is a conjugation-deconjugation cycle that targets the transcription machinery.
Lewicki Megan C MC Srikumar Tharan T Johnson Erica E Raught Brian B
Journal of proteomics 20141127
The small ubiquitin-related modifier (SUMO) "stress response" (SSR) is a poorly understood evolutionarily conserved phenomenon in which steady-state SUMO conjugate levels are dramatically increased in response to environmental stresses. Here we characterize Saccharomyces cerevisiae SSR kinetics in response to several different types of stress, demonstrate that SSR activation and inactivation do not require protein synthesis or proteasome-dependent degradation, and establish that the SSR is effec ...[more]
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