Proteomics

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Interactome of the influenza A virus transcription/replication machinery


ABSTRACT: Analyses of AP-MS experiments performed in HEK 293T cells infected with the influenza A/WSN/33 virus. In half of the experiments the virus was modified to contain a C-terminal Strep tag on the polymerase subunit PB2. Full details in York et al. 'Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.'

INSTRUMENT(S): Q Exactive

ORGANISM(S): Influenza A Virus Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Ervin Fodor 

PROVIDER: MSV000078741 | MassIVE | Mon Jun 16 06:54:00 BST 2014

REPOSITORIES: MassIVE

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Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.

York Ashley A   Hutchinson Edward C EC   Fodor Ervin E  

Journal of virology 20140903 22


<h4>Unlabelled</h4>The negative-sense RNA genome of influenza A virus is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRP). The viral RdRP is an important host range determinant, indicating that its function is affected by interactions with cellular factors. However, the identities and the roles of most of these factors remain unknown. Here, we employed affinity purification followed by mass spectrometry to identify cellular proteins that interact with the influenza A v  ...[more]

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