Dataset Information

PTMs of Endogenous Tau in Wildtype and hAPP Transgenic Mice

ABSTRACT: Please Note, if a password is required, please try "a", the generic password for Massive. These data are in support of the manuscript: Post-translational Modifications of Endogenous Tau in Wildtype and Human Amyloid Precursor Protein Transgenic Mice Meaghan Morris*a,b, Giselle M. Knudsen*c, Sumihiro Maedaa,d, Jonathan C. Trinidadc, Alexandra Ianoviciuc, Alma L. Burlingamec, Lennart Muckea,d aGladstone Institute of Neurological Disease, San Francisco, California 94158, USA bBiochemistry, Cellular and Molecular Biology Graduate Program, Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA cMass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA dDepartment of Neurology, University of California, San Francisco, California 94158, USA *These authors contributed equally to this work

INSTRUMENT(S): LTQ Orbitrap, LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Lennart Mucke

PROVIDER: MSV000078796 | MassIVE | Wed Jul 30 12:54:00 BST 2014

REPOSITORIES: MassIVE

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Publications

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.

Morris Meaghan M Knudsen Giselle M GM Maeda Sumihiro S Trinidad Jonathan C JC Ioanoviciu Alexandra A Burlingame Alma L AL Mucke Lennart L

Nature neuroscience 20150720 8

The microtubule-associated protein tau has been implicated in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Reducing tau levels ameliorates AD-related synaptic, network, and behavioral abnormalities in transgenic mice expressing human amyloid precursor protein (hAPP). We used mass spectrometry to characterize the post-translational modification of endogenous tau isolated from wild-type and hAPP mice. We identified seven types of tau modifications at 63 sites ...[more]

PMID: 26192747

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