Proteomics

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A Breast Cancer Stem Cell Niche Supported by Juxtacrine Signaling from Monocytes and Macrophages

ABSTRACT: Lu H, Clauser KR, Tam WL, Fröse J, Ye X, Eaton EN, Reinhart F, Donnenberg VS, Bhargava R, Carr SA, Weinberg RA, Nature Cell Biol 2014 in press

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Steven A. Carr 

PROVIDER: MSV000078799 | MassIVE | Mon Aug 04 06:30:00 BST 2014

REPOSITORIES: MassIVE

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Publications

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.

Lu Haihui H   Clauser Karl R KR   Tam Wai Leong WL   Fröse Julia J   Ye Xin X   Eaton Elinor Ng EN   Reinhardt Ferenc F   Donnenberg Vera S VS   Bhargava Rohit R   Carr Steven A SA   Weinberg Robert A RA  

Nature cell biology 20140928 11

The cell-biological program termed the epithelial-mesenchymal transition (EMT) confers on cancer cells mesenchymal traits and an ability to enter the cancer stem cell (CSC) state. However, the interactions between CSCs and their surrounding microenvironment are poorly understood. Here we show that tumour-associated monocytes and macrophages (TAMs) create a CSC niche through juxtacrine signalling with CSCs. We performed quantitative proteomic profiling and found that the EMT program upregulates t  ...[more]