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Myotubularin-related proteins control abscission_StDenis_MTMR_P84_VS6-7-8-11-12

ABSTRACT: This submission is part of the mass spectrometry datasets for the manuscript by St-Denis et al. entitled: Myotubularin-related proteins 3 & 4 interact with PLK1 and CEP55 to control CEP55 recruitment to the midbody and ensure proper abscission. This submission contains 82 RAW files and 82 mgf files, all acquired on a Velos Orbitrap mass spectrometer, as well as results files. See the README file within Methods and Protocols and the accompanying File description.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras

PROVIDER: MSV000078915 | MassIVE | Thu Oct 30 13:40:00 GMT 2014

SECONDARY ACCESSION(S): PXD001448

REPOSITORIES: MassIVE

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Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

St-Denis Nicole N Gupta Gagan D GD Lin Zhen Yuan ZY Gonzalez-Badillo Beatriz B Pelletier Laurence L Gingras Anne-Claude AC

Molecular & cellular proteomics : MCP 20150206 4

The myotubularins are a family of phosphatases that dephosphorylate the phosphatidylinositols phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-phosphate. Several family members are mutated in disease, yet the biological functions of the majority of myotubularins remain unknown. To gain insight into the roles of the individual enzymes, we have used affinity purification coupled to mass spectrometry to identify protein-protein interactions for the myotubularins. The myotubularin inter ...[more]

PMID: 25659891

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