Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA256212GSE59793PRJNA256196PRJNA256211
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: Steven A. Carr
PROVIDER: MSV000078994 | MassIVE | Thu Jan 15 08:19:00 GMT 2015
REPOSITORIES: MassIVE
Science (New York, N.Y.) 20150212 6226
Protein expression is regulated by the production and degradation of messenger RNAs (mRNAs) and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics so as to build a quantitative genomic model of the differential regulation of gene expression in lipopolysaccharide-stimulated mouse dendritic cells. Changes in mRNA abundance play a dominant role in determining most dynamic fold changes in protein levels. Converse ...[more]