Proteomics

Dataset Information

0

Lenalidomide induces ubiquitination and degradation of casein kinase 1A1 in del(5q) MDS


ABSTRACT:

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Steven A. Carr 

PROVIDER: MSV000079014 | MassIVE | Mon Jan 26 06:47:00 GMT 2015

REPOSITORIES: MassIVE

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1
altmetric image

Publications


Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)), resulting in CK1α degradation. CK1α is encoded by a gene within the common deleted region for del(5q) MDS and haploinsufficient expression sensitizes cells to lenalidomide therapy, providing a mechanistic basis for  ...[more]

Similar Datasets

| S-EPMC2937986 | biostudies-literature
| S-EPMC4853910 | biostudies-literature
| S-EPMC2650345 | biostudies-literature
| S-EPMC1221594 | biostudies-other
| S-EPMC5668205 | biostudies-literature
| S-EPMC4135596 | biostudies-literature
| S-EPMC8340461 | biostudies-literature
| S-EPMC2518423 | biostudies-literature
| S-EPMC1618114 | biostudies-literature
| S-EPMC6055794 | biostudies-literature