Dataset Information

Uuskula_P112_VS2_TOP2B_BioID_15JUN2015

ABSTRACT: This submission contains the mass spectrometry files for the manuscript by Uuskula-Reimand et al. that investigates the interactome of TOP2B using BioID and its genomic binding profile. This submission contains 18 IDA files for the following baits: empty 3XFLAG control, GFP-BirA-FLAG control, NLS-BirA-FLAG control, TOP2B-BirA-FLAG. See the README file within "Methods and Protocols" and the accompanying File description.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Gingras

PROVIDER: MSV000079188 | MassIVE | Fri Jul 10 14:59:00 BST 2015

SECONDARY ACCESSION(S): PXD004717

REPOSITORIES: MassIVE

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Publications

Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.

Uusküla-Reimand Liis L Hou Huayun H Samavarchi-Tehrani Payman P Rudan Matteo Vietri MV Liang Minggao M Medina-Rivera Alejandra A Mohammed Hisham H Schmidt Dominic D Schwalie Petra P Young Edwin J EJ Reimand Jüri J Hadjur Suzana S Gingras Anne-Claude AC Wilson Michael D MD

Genome biology 20160831 1

<h4>Background</h4>Type II DNA topoisomerases (TOP2) regulate DNA topology by generating transient double stranded breaks during replication and transcription. Topoisomerase II beta (TOP2B) facilitates rapid gene expression and functions at the later stages of development and differentiation. To gain new insight into the genome biology of TOP2B, we used proteomics (BioID), chromatin immunoprecipitation, and high-throughput chromosome conformation capture (Hi-C) to identify novel proximal TOP2B p ...[more]

PMID: 27582050

Dataset Information

Uuskula_P112_VS2_TOP2B_BioID_15JUN2015

Dataset's files

Publications

Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.

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