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Colonic metaproteomic signatures of active bacteria and the host in obesity

ABSTRACT: Colonic metaproteomic signatures of active bacteria and the host in obesity

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Metaproteome

SUBMITTER: Willem M. de Vos

PROVIDER: MSV000079242 | MassIVE | Sat Aug 15 05:54:00 BST 2015

REPOSITORIES: MassIVE

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Colonic metaproteomic signatures of active bacteria and the host in obesity.

Kolmeder Carolin A CA Ritari Jarmo J Verdam Froukje J FJ Muth Thilo T Keskitalo Salla S Varjosalo Markku M Fuentes Susana S Greve Jan Willem JW Buurman Wim A WA Reichl Udo U Rapp Erdmann E Martens Lennart L Palva Airi A Salonen Anne A Rensen Sander S SS de Vos Willem M WM

Proteomics 20150911 20

Obesity is associated with the intestinal microbiota in humans but the underlying mechanisms are yet to be fully understood. Our previous phylogenetic study showed that the faecal microbiota profiles of nonobese versus obese and morbidly obese individuals differed. Here, we have extended this analysis with a characterization of the faecal metaproteome, in order to detect differences at a functional level. Proteins were extracted from crude faecal samples of 29 subjects, separated by 1D gel elect ...[more]

PMID: 26255997

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