Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)
SUBMITTER: Dr. Roberto M. Vanacore
PROVIDER: MSV000079260 | MassIVE | Mon Aug 17 20:38:00 BST 2015
SECONDARY ACCESSION(S): PXD003237
REPOSITORIES: MassIVE
Journal of proteome research 20151209 1
Collagen IV is the main structural protein that provides a scaffold for assembly of basement membrane proteins. Posttranslational modifications such as hydroxylation of proline and lysine and glycosylation of lysine are essential for the functioning of collagen IV triple-helical molecules. These modifications are highly abundant posing a difficult challenge for in-depth characterization of collagen IV using conventional proteomics approaches. Herein, we implemented an integrated pipeline combini ...[more]