Proteomics

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Mining the Human Urine Proteome for Monitoring Renal Transplant Injury


ABSTRACT: a) 8-plex iTRAQ-based quantitative proteomics analysis of the urine proteome comparing 4 different clinical conditions; b) Label-free LC-MS analyses of individual urine samples from different clinical conditions

OTHER RELATED OMICS DATASETS IN: PRJNA305092

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Minnie M. Sarwal and David G. Camp 

PROVIDER: MSV000079262 | MassIVE | Tue Aug 18 11:49:00 BST 2015

SECONDARY ACCESSION(S): PXD002761

REPOSITORIES: MassIVE

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The human urinary proteome provides an assessment of kidney injury with specific biomarkers for different kidney injury phenotypes. In an effort to fully map and decipher changes in the urine proteome and peptidome after kidney transplantation, renal allograft biopsy matched urine samples were collected from 396 kidney transplant recipients. Centralized and blinded histology data from paired graft biopsies was used to classify urine samples into diagnostic categories of acute rejection, chronic  ...[more]

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