Dataset Information
Anania et al. 2015. Caspase substrate profiling
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Jennie Lill
PROVIDER: MSV000079302 | MassIVE |
SECONDARY ACCESSION(S): PXD002876
REPOSITORIES: MassIVE
Publications
Uncovering a Dual Regulatory Role for Caspases During Endoplasmic Reticulum Stress-induced Cell Death.
Molecular & cellular proteomics : MCP 20160428 7
Many diseases are associated with endoplasmic reticulum (ER) stress, which results from an accumulation of misfolded proteins. This triggers an adaptive response called the "unfolded protein response" (UPR), and prolonged exposure to ER stress leads to cell death. Caspases are reported to play a critical role in ER stress-induced cell death but the underlying mechanisms by which they exert their effect continue to remain elusive. To understand the role caspases play during ER stress, a systems l ...[more]
