Proteomics

Dataset Information

0

Anania et al. 2015. Caspase substrate profiling


ABSTRACT: raw mass spec data set associated with Anania et al. manuscript

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Jennie Lill 

PROVIDER: MSV000079302 | MassIVE |

SECONDARY ACCESSION(S): PXD002876

REPOSITORIES: MassIVE

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Publications

Uncovering a Dual Regulatory Role for Caspases During Endoplasmic Reticulum Stress-induced Cell Death.

Anania Veronica G VG   Yu Kebing K   Gnad Florian F   Pferdehirt Rebecca R RR   Li Han H   Ma Taylur P TP   Jeon Diana D   Fortelny Nikolaus N   Forrest William W   Ashkenazi Avi A   Overall Christopher M CM   Lill Jennie R JR  

Molecular & cellular proteomics : MCP 20160428 7


Many diseases are associated with endoplasmic reticulum (ER) stress, which results from an accumulation of misfolded proteins. This triggers an adaptive response called the "unfolded protein response" (UPR), and prolonged exposure to ER stress leads to cell death. Caspases are reported to play a critical role in ER stress-induced cell death but the underlying mechanisms by which they exert their effect continue to remain elusive. To understand the role caspases play during ER stress, a systems l  ...[more]

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