Proteomics

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Proteome analyses of the human anterior temporal lobe

ABSTRACT: Characterization of the human Anterior Temporal Lobe and Corpus Callosum: C-HPP

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Daniel Martins-de-Souza 

PROVIDER: MSV000079590 | MassIVE | Wed Mar 16 09:54:00 GMT 2016

SECONDARY ACCESSION(S): PXD000548

REPOSITORIES: MassIVE

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Publications

Deciphering the human brain proteome: characterization of the anterior temporal lobe and corpus callosum as part of the Chromosome 15-centric Human Proteome Project.

Martins-de-Souza Daniel D   Carvalho Paulo C PC   Schmitt Andrea A   Junqueira Magno M   Nogueira Fábio C S FC   Turck Christoph W CW   Domont Gilberto B GB  

Journal of proteome research 20131203 1

Defining the proteomes encoded by each chromosome and characterizing proteins related to human illnesses are among the goals of the Chromosome-centric Human Proteome Project (C-HPP) and the Biology and Disease-driven HPP. Following these objectives, we investigated the proteomes of the human anterior temporal lobe (ATL) and corpus callosum (CC) collected post-mortem from eight subjects. Using a label-free GeLC-MS/MS approach, we identified 2454 proteins in the ATL and 1887 in the CC through roug  ...[more]