Proteomics

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Proteome profiling of ovarian cancer and cirrhosis ascites

ABSTRACT: Proteome-metabolome profiling of ovarian cancer ascites reveals novel components involved in intercellular communication http://www.mcponline.org/content/early/2014/09/30/mcp.M114.041194.full.pdf+html?sid=78e7a955-fa54-4ded-b296-89f1fb6adbec

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Georgij Arapidi 

PROVIDER: MSV000079934 | MassIVE | Tue Jul 19 20:31:00 BST 2016

SECONDARY ACCESSION(S): PXD001403

REPOSITORIES: MassIVE

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Publications

Ovarian cancer ascites is a native medium for cancer cells that allows investigation of their secretome in a natural environment. This medium is of interest as a promising source of potential biomarkers, and also as a medium for cell-cell communication. The aim of this study was to elucidate specific features of the malignant ascites metabolome and proteome. In order to omit components of the systemic response to ascites formation, we compared malignant ascites with cirrhosis ascites. Metabolome  ...[more]