Proteomics

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Proteome profiling of human myoblastic RCMH cell line

ABSTRACT: The study aimed to comprehensively characterize human myoblastic cell line RCMH using using electron microscopic and proteomic approaches. Myoblastic cell lines can be useful to investigate the complex biochemical changes occuring under different conditions that reflect the physiological and pathophysiological mechanisms of muscle. So far, there are no suitable in vitro models of human muscle origin to study a variety of muscle related processes including responses to mechanical stress, EC-coupling and (ER-associated) myopathic disorders. Therefore, we characterized the human immortal myoblastic cell line RCMH and the results suggest RCMH as a suitable in vitro model for investigating human muscle related processes and disorders.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Ren�� P. Zahedi 

PROVIDER: MSV000079948 | MassIVE | Wed Jul 20 10:30:00 BST 2016

SECONDARY ACCESSION(S): PXD001974

REPOSITORIES: MassIVE

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Proteome Profiling and Ultrastructural Characterization of the Human RCMH Cell Line: Myoblastic Properties and Suitability for Myopathological Studies.

Kollipara Laxmikanth L   Buchkremer Stephan S   Weis Joachim J   Brauers Eva E   Hoss Mareike M   Rütten Stephan S   Caviedes Pablo P   Zahedi René P RP   Roos Andreas A  

Journal of proteome research 20160215 3

Studying (neuro)muscular disorders is a major topic in biomedicine with a demand for suitable model systems. Continuous cell culture (in vitro) systems have several technical advantages over in vivo systems and became widely used tools for discovering physiological/pathophysiological mechanisms in muscle. In particular, myoblast cell lines are suitable model systems to study complex biochemical adaptations occurring in skeletal muscle and cellular responses to altered genetic/environmental condi  ...[more]

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