Dataset Information

Human oral cancer brush biopsy iTRAQ

ABSTRACT: iTRAQ-based comparison of proteins derived from oral cells collected by brush biopsy. Protein abundance levels compared between oral pre-malignant cells, oral cancer cells and healthy normal cells, all collected from human patients. Two separate iTRAQ labeled biological replicate analyses were conducted.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Timothy Jon Griffin

PROVIDER: MSV000079994 | MassIVE | Fri Jul 22 16:09:00 BST 2016

SECONDARY ACCESSION(S): PXD000807

REPOSITORIES: MassIVE

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Publications

Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker.

Yang Ya Y Rhodus Nelson L NL Ondrey Frank G FG Wuertz Beverly R K BR Chen Xiaobing X Zhu Yaqin Y Griffin Timothy J TJ

PloS one 20140418 4

A decrease in the almost fifty percent mortality rate from oral cancer is needed urgently. Improvements in early diagnosis and more effective preventive treatments could affect such a decrease. Towards this end, we undertook for the first time an in-depth mass spectrometry-based quantitative shotgun proteomics study of non-invasively collected oral brush biopsies. Proteins isolated from brush biopsies from healthy normal tissue, oral premalignant lesion tissue (OPMLs), oral squamous cell carcino ...[more]

PMID: 24748380

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