Proteomics

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HipSci project pilot submission for 18 IPS cell lines

ABSTRACT: The Human Induced Pluripotent Stem Cells Initiative (HipSci) is generating a large, high-quality reference panel of human IPSC lines. This is a pilot submission of mass-spectrometry analyses from 18 induced pluripotent stem cell lines generated by the HipSci project. This submission includes also data for two embryonic stem cell lines, and one reference sample comprising a mixture of 42 IPSC lines. Associated BioSamples accessions: SAMEA2397999, SAMEA2398167, SAMEA2398916, SAMEA2397948 , SAMEA2399112,SAMEA2399257, SAMEA2398553, SAMEA2398821, SAMEA2398316, SAMEA2469778, SAMEA2399037, SAMEA2398656, SAMEA2398428, SAMEA2469777, SAMEA2397959, SAMEA2398442, SAMEA2398024, SAMEA2398450, SAMEA3402864, SAMEA3110364

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Angus Lamond 

PROVIDER: MSV000080004 | MassIVE | Sun Jul 24 13:15:00 BST 2016

SECONDARY ACCESSION(S): PXD003903

REPOSITORIES: MassIVE

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Publications

Common genetic variation drives molecular heterogeneity in human iPSCs.

Kilpinen Helena H   Goncalves Angela A   Leha Andreas A   Afzal Vackar V   Alasoo Kaur K   Ashford Sofie S   Bala Sendu S   Bensaddek Dalila D   Casale Francesco Paolo FP   Culley Oliver J OJ   Danecek Petr P   Faulconbridge Adam A   Harrison Peter W PW   Kathuria Annie A   McCarthy Davis D   McCarthy Shane A SA   Meleckyte Ruta R   Memari Yasin Y   Moens Nathalie N   Soares Filipa F   Mann Alice A   Streeter Ian I   Agu Chukwuma A CA   Alderton Alex A   Nelson Rachel R   Harper Sarah S   Patel Minal M   White Alistair A   Patel Sharad R SR   Clarke Laura L   Halai Reena R   Kirton Christopher M CM   Kolb-Kokocinski Anja A   Beales Philip P   Birney Ewan E   Danovi Davide D   Lamond Angus I AI   Ouwehand Willem H WH   Vallier Ludovic L   Watt Fiona M FM   Durbin Richard R   Stegle Oliver O   Gaffney Daniel J DJ  

Nature 20170510 7658

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease. However, variable genetic and phenotypic characterization of many existing iPS cell lines limits their potential use for research and therapy. Here we describe the systematic generation, genotyping and phenotyping of 711 iPS cell lines derived from 301 healthy individuals by the Human Induced Pluripotent Stem Cells Initiative. Our study outlines the m  ...[more]

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