Proteomics

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Uninfected and human respiratory syncytial virus (RSV)-infected A549 cells, analysed using bottom-up mass spectrometry


ABSTRACT: Proteomic data from uninfected and human respiratory syncytial virus (RSV) infected A549 cells (24h post infection; four biological replicate sets). Data is related to the fractionation-free workflow described in Dave et al. (2014) (PMID: 25106423). Data is processed using MaxQuant (version 1.3.0.5).

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Respiratory Syncytial Virus A2 (ncbitaxon:11259)

SUBMITTER: Jeffrey J Gorman 

PROVIDER: MSV000080032 | MassIVE | Mon Aug 08 16:56:00 BST 2016

SECONDARY ACCESSION(S): PXD004738

REPOSITORIES: MassIVE

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Publications

A comprehensive proteomic view of responses of A549 type II alveolar epithelial cells to human respiratory syncytial virus infection.

Dave Keyur A KA   Norris Emma L EL   Bukreyev Alexander A AA   Headlam Madeleine J MJ   Buchholz Ursula J UJ   Singh Toshna T   Collins Peter L PL   Gorman Jeffrey J JJ  

Molecular & cellular proteomics : MCP 20140808 12


Human respiratory syncytial virus is a major respiratory pathogen for which there are no suitable antivirals or vaccines. A better understanding of the host cell response to this virus may redress this problem. The present report concerns analysis of multiple independent biological replicates of control and 24 h infected lysates of A549 cells by two different proteomic workflows. One workflow involved fractionation of lysates by in-solution protein IEF and individual fractions were digested usin  ...[more]

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