Dataset Information
Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap Discovery
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: Anthony O. Gramolini
PROVIDER: MSV000080038 | MassIVE | Fri Aug 12 11:37:00 BST 2016
SECONDARY ACCESSION(S): PXD004784
REPOSITORIES: MassIVE
Publications
Hypoxia-Induced Changes in the Fibroblast Secretome, Exosome, and Whole-Cell Proteome Using Cultured, Cardiac-Derived Cells Isolated from Neonatal Mice.
Journal of proteome research 20170706 8
Cardiac fibroblasts (CFs) represent a major subpopulation of cells in the developing and adult heart. Cardiomyocyte (CM) and CF intercellular communication occurs through paracrine interactions and modulate myocyte development and stress response. Detailed proteomic analysis of the CF secretome in normal and stressed conditions may offer insights into the role of CF in heart development and disease. Primary neonatal mouse CFs were isolated and cultured for 24 h in 21% (normoxic) or 2% (hypoxic) ...[more]
