Proteomics

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The proteome of localized prostate cancer, part 1

ABSTRACT: Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PXD003452, PXD003515, PXD004132, PXD003615, PXD003636, PXD004159.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Amilcar Flores-Morales 

PROVIDER: MSV000080069 | MassIVE | Thu Aug 18 12:20:00 BST 2016

SECONDARY ACCESSION(S): PXD003430

REPOSITORIES: MassIVE

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<h4>Background</h4>Clinical management of the prostate needs improved prognostic tests and treatment strategies. Because proteins are the ultimate effectors of most cellular reactions, are targets for drug actions and constitute potential biomarkers; a quantitative systemic overview of the proteome changes occurring during prostate cancer (PCa) initiation and progression can result in clinically relevant discoveries.<h4>Objectives</h4>To study cellular processes altered in PCa using system-wide  ...[more]

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