Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Dr Jyrki Heino
PROVIDER: MSV000080224 | MassIVE | Tue Oct 04 14:26:00 BST 2016
SECONDARY ACCESSION(S): PXD003132
REPOSITORIES: MassIVE
Sipilä Kalle H KH Ranga Vipin V Rappu Pekka P Torittu Annamari A Pirilä Laura L Käpylä Jarmo J Johnson Mark S MS Larjava Hannu H Heino Jyrki J
Matrix biology : journal of the International Society for Matrix Biology 20160303
In inflammatory arthritis peptidyl arginine deiminase (PAD) enzymes can citrullinate arginine residues in extracellular matrix (ECM) proteins, such as collagens and fibronectin. This may lead to the generation of anti-citrullinated protein antibodies, important diagnostic markers in rheumatoid arthritis. In addition, the citrullination may directly affect protein function. Based on structural analysis, we found that most ECM-associated growth factors (GFs) have arginine residues in their recepto ...[more]