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Proteomic data of Tetragenococcus halophilus

ABSTRACT: The raw spectrum data of the proteomic study of Tetragenococcus halophilus under hypo-osmotics stress condition and hyper-osmotic stress condition, the data was generated by combining isobaric laveling regents TMT and reverse phase HPLC-MS/MS.

INSTRUMENT(S): Isobaric labeling reagents Tandem Mass Tags, Reverse Phase HPLC-MS/MS

ORGANISM(S): Tetragenococcus Halophilus Cicc 10469

SUBMITTER: Lixin Luo

PROVIDER: MSV000080520 | MassIVE | Tue Jan 31 03:25:00 GMT 2017

REPOSITORIES: MassIVE

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Project description:Talemi2016 - Yeast osmo-homoestasis This model is described in the article: Systems Level Analysis of the Yeast Osmo-Stat. Talemi SR, Tiger CF, Andersson M, Babazadeh R, Welkenhuysen N, Klipp E, Hohmann S, Schaber J. Sci Rep 2016; 6: 30950 Abstract: Adaptation is an important property of living organisms enabling them to cope with environmental stress and maintaining homeostasis. Adaptation is mediated by signaling pathways responding to different stimuli. Those signaling pathways might communicate in order to orchestrate the cellular response to multiple simultaneous stimuli, a phenomenon called crosstalk. Here, we investigate possible mechanisms of crosstalk between the High Osmolarity Glycerol (HOG) and the Cell Wall Integrity (CWI) pathways in yeast, which mediate adaptation to hyper- and hypo-osmotic challenges, respectively. We combine ensemble modeling with experimental investigations to test in quantitative terms different hypotheses about the crosstalk of the HOG and the CWI pathways. Our analyses indicate that for the conditions studied i) the CWI pathway activation employs an adaptive mechanism with a variable volume-dependent threshold, in contrast to the HOG pathway, whose activation relies on a fixed volume-dependent threshold, ii) there is no or little direct crosstalk between the HOG and CWI pathways, and iii) its mainly the HOG alone mediating adaptation of cellular osmotic pressure for both hyper- as well as hypo-osmotic stress. Thus, by iteratively combining mathematical modeling with experimentation we achieved a better understanding of regulatory mechanisms of yeast osmo-homeostasis and formulated new hypotheses about osmo-sensing. This model is hosted on BioModels Database and identified by: MODEL1606100000. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

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Proteomic data of Tetragenococcus halophilus

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