Dataset Information
Estrogen Receptor Mutant Coregulator
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Velos Plus, LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Sung Yun Jung Foulds, Charles E
PROVIDER: MSV000080536 | MassIVE | Wed Feb 08 14:13:00 GMT 2017
SECONDARY ACCESSION(S): PXD005887
REPOSITORIES: MassIVE
Publications
Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets.
Oncogene 20180511 33
Approximately 75% of breast cancers are estrogen receptor alpha (ERα)-positive and are treatable with endocrine therapies, but often patients develop lethal resistant disease. Frequent mutations (10-40%) in the ligand-binding domain (LBD) codons in the gene encoding ERα (ESR1) have been identified, resulting in ligand-independent, constitutively active receptors. In addition, ESR1 chromosomal translocations can occur, resulting in fusion proteins that lack the LBD and are entirely unresponsive t ...[more]
