Proteomics

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Chlamydia trachomatis ChxR is a transcriptional regulator of virulence factors that function in in vivo host pathogen interactions


ABSTRACT: To identify potential chlamydia genes that were regulated by the transcriptional enhancer chxR, we did a full proteome analysis of HeLa cells infected with the three independent chxR mutants. This lead to the discovery of a common set of five proteins (CT005, CT214, CT565, CT694, CT695) that were significantly down regulated in all three mutants, suggesting that their expression was regulated by chxR. Importantly, each of the five were free of any mutations and thus were not direct targets of the EMS treatment.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Chlamydia Trachomatis (ncbitaxon:813) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Grant McClarty  

PROVIDER: MSV000080635 | MassIVE | Wed Mar 15 15:08:00 GMT 2017

SECONDARY ACCESSION(S): PXD006101

REPOSITORIES: MassIVE

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