Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PXD001805E-MTAB-3649
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Pascale Cossart
PROVIDER: MSV000080750 | MassIVE | Wed Mar 29 05:50:00 BST 2017
SECONDARY ACCESSION(S): PXD001805
REPOSITORIES: MassIVE
eLife 20150811
ISG15 is an interferon-stimulated, linear di-ubiquitin-like protein, with anti-viral activity. The role of ISG15 during bacterial infection remains elusive. We show that ISG15 expression in nonphagocytic cells is dramatically induced upon Listeria infection. Surprisingly this induction can be type I interferon independent and depends on the cytosolic surveillance pathway, which senses bacterial DNA and signals through STING, TBK1, IRF3 and IRF7. Most importantly, we observed that ISG15 expressio ...[more]